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KMID : 1130320080510091007
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Korean Journal of Pediatrics
2008 Volume.51 No. 9 p.1007 ~ p.1011
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Polymorphisms of interleukin-1β promoter in simple febrile seizures
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Yoon Jang-Won
Cheon Eun-Jung
Lee Young-Hyuk
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Abstract
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Purpose: Febrile seizure (FS) is the most common type of seizure. The role of genetic factors in FSs has long been recognized. A positive family history can be elicited in 25-40% of patients with FSs; nonetheless, the genes responsible for FSs in the majority of the population remain unknown. Interleukin-1beta (IL-1beta) is a pro-inflammatory cytokine that acts as an endogenous pyrogen. Thus, IL-1beta could be involved in the pathophysiology of FSs.
Methods: To determine whether or not single nucleotide polymorphisms of the IL-1beta gene are associated with susceptibility to simple FSs, IL-1beta promoter -31 and -511 genotyping was performed by means of polymerase chain reaction-restriction fragment (PCR-RF) length polymorphism in 40 FS patients (20 sporadic and 20 familial FS patients) and 33 controls.
Results: There were no significant differences in the frequencies of -31 C/T and -511 C/T in the IL-1beta promoter gene, between simple FS patients and controls.
Conclusion The frequency of CT/CT increased relatively in familial FS patients. A study examining a larger number of FS patients is needed.
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KEYWORD
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Simple febrile seizures, Interleukin-1β
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